diff --git a/vm-virtio/src/lib.rs b/vm-virtio/src/lib.rs
index ceed3ccdb..5956c592b 100755
--- a/vm-virtio/src/lib.rs
+++ b/vm-virtio/src/lib.rs
@@ -128,6 +128,7 @@ impl fmt::Display for VirtioDeviceType {
 const INTERRUPT_STATUS_USED_RING: u32 = 0x1;
 #[allow(dead_code)]
 const INTERRUPT_STATUS_CONFIG_CHANGED: u32 = 0x2;
+const VIRTIO_MSI_NO_VECTOR: u16 = 0xffff;
 
 #[derive(Debug)]
 pub enum ActivateError {
diff --git a/vm-virtio/src/transport/pci_device.rs b/vm-virtio/src/transport/pci_device.rs
index 15f976b85..ff86fad56 100755
--- a/vm-virtio/src/transport/pci_device.rs
+++ b/vm-virtio/src/transport/pci_device.rs
@@ -37,6 +37,7 @@ use crate::{
     Queue, VirtioDevice, VirtioDeviceType, VirtioInterrupt, VirtioInterruptType,
     VirtioIommuRemapping, DEVICE_ACKNOWLEDGE, DEVICE_DRIVER, DEVICE_DRIVER_OK, DEVICE_FAILED,
     DEVICE_FEATURES_OK, DEVICE_INIT, INTERRUPT_STATUS_CONFIG_CHANGED, INTERRUPT_STATUS_USED_RING,
+    VIRTIO_MSI_NO_VECTOR,
 };
 
 #[allow(clippy::enum_variant_names)]
@@ -510,6 +511,10 @@ impl PciDevice for VirtioPciDevice {
                         }
                     };
 
+                    if vector == VIRTIO_MSI_NO_VECTOR {
+                        return Ok(());
+                    }
+
                     let config = &mut msix_config_clone.lock().unwrap();
                     let entry = &config.table_entries[vector as usize];