diff --git a/pci/src/vfio.rs b/pci/src/vfio.rs
index 53c77a95c..0fa3ae836 100644
--- a/pci/src/vfio.rs
+++ b/pci/src/vfio.rs
@@ -158,6 +158,10 @@ impl VfioMsix {
         // Update "Message Control" word
         if offset == 2 && data.len() == 2 {
             self.bar.set_msg_ctl(LittleEndian::read_u16(data));
+        } else if offset == 0 && data.len() == 4 {
+            // Some guests update MSI-X control through the dword config write path.
+            self.bar
+                .set_msg_ctl((LittleEndian::read_u32(data) >> 16) as u16);
         }
 
         let new_enabled = self.bar.enabled();